PROTe-IN's Continuous Fermentation Aims to Turn CO₂ Into Collagen

The Italian biotech startup, backed by Mondelēz and EIT Food, is licensing a bioreactor system to food manufacturers from Bologna to Dubai.

About PROTe-IN

Published

The first thing you notice about PROTe-IN’s pitch is the font. It’s a clean, modern sans-serif, rendered in a palette of earthy greens and blues, and it sits atop a website that feels more like a design agency’s portfolio than a deeptech startup’s lab notes. The second thing you notice is the claim, rendered in that same confident typeface: for every kilogram of single-cell protein it produces, the process captures 1.8 kilograms of carbon dioxide [LinkedIn, retrieved 2024]. It’s a promise that turns the traditional food production narrative inside out. Instead of a carbon cost, you get a carbon credit, baked into the ingredient itself. The interface suggests a world where sustainability is not a compromise but a core product spec, and PROTe-IN is selling the machine to make it.

The Continuous Bet

At its core, PROTe-IN is a bet on process over product. While competitors like Solar Foods and Air Protein are also pioneering air-derived proteins, PROTe-IN’s stated wedge is its proprietary continuous fermentation technology. The company claims this method is up to three times more efficient than traditional batch fermentation, a significant lever for unit economics in a capital-intensive field [EIT Food, retrieved 2024]. Their business model is deliberately asset-light: they don’t aim to become a massive ingredient producer themselves. Instead, they plan to license the software, machinery, and applications to established food manufacturers and ingredient companies, alongside conducting paid R&D projects [Startup Centrum, retrieved 2024]. It’s a play to become the Intel Inside for a new generation of carbon-negative ingredients, embedding their technology in other companies’ supply chains.

A Founders’ Bridge from Brand to Bioreactor

The founding team, two Guidos from Italy, represents a deliberate bridge between two worlds. Guido Mercati, the CEO, brings over two decades of brand strategy and digital experience from tenures at Accenture, Publicis, and WPP [Saudi Food Manufacturing, Sep 2026]. His co-founder, Guido Ferralasco, is the operations director, a former top executive at confectionery giant Ferrero with deep experience in global manufacturing and supply chains [F6S, retrieved 2024]. This pairing is the startup’s answer to a classic deeptech challenge: the need for both technical ambition and commercial pragmatism. Mercati provides the narrative and connections into the world of global brands and investors, while Ferralasco understands the gritty realities of scaling food production. Their backgrounds suggest a company built not just to invent a process, but to install it.

Traction Through Partnership

Evidence of early execution comes in the form of strategic relationships rather than shipped product. PROTe-IN has been backed by the EIT Food accelerator and the CoLab Tech Accelerator, and lists Mondelēz International, BioEconomy Ventures, and Dr. Jean Yu among its investor relationships [F6S, retrieved 2024] [PitchBook, retrieved 2024]. The connection to a snack-food titan like Mondelēz is particularly telling, pointing to potential early interest from a major player seeking future-fit ingredients. Furthermore, CEO Guido Mercati has publicly stated plans to establish a collagen production line within Dubai’s Food Tech Valley, a government-backed hub, suggesting advanced conversations with regional partners [Indiatimes, retrieved 2026]. The company’s commercial pipeline reportedly includes discussions with firms like Agthia, Kerry, and IFF for proof-of-concept projects [Startup Centrum, retrieved 2024].

Founder Role Key Background
Guido Mercati Co-Founder & CEO 20+ years in digital strategy at Accenture, Publicis, WPP; mentor at Techstars & Founder Institute [Saudi Food Manufacturing, Sep 2026] [F6S, retrieved 2024]
Guido Ferralasco Co-Founder & Operations Director Former top executive at Ferrero with 20+ years in operations [F6S, retrieved 2024]

The Scale-Up Question

For all its promising positioning, PROTe-IN’s path is lined with the formidable hurdles of industrial biotech. The company’s efficiency and carbon-capture metrics remain company claims, awaiting the independent validation that will be crucial for convincing large, risk-averse food conglomerates to retrofit their production lines [EIT Food, retrieved 2024] [LinkedIn, retrieved 2024]. The competitive field is also advancing rapidly, with well-funded players pursuing similar visions of gas fermentation.

The company’s near-term risks can be framed around three core challenges:

  • Technical Validation. The leap from lab-scale claims to consistent, cost-effective performance at pilot-plant scale is the single biggest gating factor for the entire business model.
  • Capital Intensity. While asset-light, developing and proving continuous bioreactor systems is expensive. The undisclosed nature of funding to date makes it difficult to assess their runway for this critical phase [F6S, retrieved 2024].
  • Commercial Pilots. Converting discussions with names like Kerry and IFF into contracted, paying pilot projects is the essential next step to demonstrate market fit and generate the case studies needed for wider adoption.

The Next Twelve Months

The coming year will be defined by a shift from narrative to tangible proof. The stated plan for a collagen production line in Dubai is the key milestone to watch. Progress there would signal not just technical viability, but also the ability to navigate complex partnerships and regional regulations. Success will likely necessitate a significant, disclosed funding round to move from prototype to pilot plant. For a company built on a licensing model, the first signed deal with a food manufacturer to embed PROTe-IN’s technology will be the ultimate traction signal, turning their elegant website claims into a line item on a factory floor.

The ambition here isn’t merely to make protein from air. It’s to design a system where the very act of production heals, however fractionally, the environmental ledger. PROTe-IN is betting that the future of food isn’t found in a new seed or a lab-grown steak, but in the quiet hum of a bioreactor that treats the atmosphere as its feedstock. The question they are implicitly answering is a profound one for our age: in a world of constrained resources, can we build machines that are net-positive by design? Their font choice suggests they believe the answer should at least look beautiful.

Sources

  1. [EIT Food, retrieved 2024] PROTe-IN accelerator profile | https://www.eitfood.eu/community/startups/eitfoodacceleratornetwork-prote-in
  2. [F6S, retrieved 2024] PROTe-IN company and team profile | https://www.f6s.com/company/prote-in
  3. [Indiatimes, retrieved 2026] Guido Mercati on plans for Dubai's Food Tech Valley | https://www.indiatimes.com/technology/news/prote-in-dubai-food-tech-valley-687421.html
  4. [LinkedIn, retrieved 2024] PROTe-IN company claims on CO₂ capture | https://www.linkedin.com/company/prote-in
  5. [PitchBook, retrieved 2024] PROTe-IN funding and accelerator details | https://pitchbook.com/profiles/company/520639-57
  6. [Saudi Food Manufacturing, Sep 2026] Guido Mercati speaker biography | https://www.saudifoodmanufacturing.com/speakers/guido-mercati
  7. [Startup Centrum, retrieved 2024] PROTe-IN business model and pipeline details | https://startupcentrum.com/startup/prote-in

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